The Acute and Chronic Cognitive Effects of a Sage Extract: A Randomized, Placebo Controlled Study in Healthy Humans

The sage (Salvia) plant contains a host of terpenes and phenolics which interact with mechanisms pertinent to brain function improve aspects cognitive performance. However, previous studies in humans have looked at these phytochemicals isolation following acute consumption only. A preclinical vivo study rodents, however, has demonstrated improved outcomes 2-week CogniviaTM, proprietary extract both Salvia officinalis polyphenols lavandulaefolia terpenoids, suggesting that combination from might be more efficacious over longer period time. current investigated the impact this on functions chronic outcomes. Participants (n = 94, 25 M, 69 F, 30–60 years old) took part randomised, double-blind, placebo-controlled, parallel groups design where comprehensive array cognitions were assessed 120- 240-min post-dose acutely 29-day supplementation either 600 mg or placebo. consistent, significant benefit was observed throughout working memory accuracy task outcome measures (specifically Corsi Blocks, Numeric Working Memory, Name Face Recall tasks) (i.e., changes within day 1 29) chronically between 29). These results fall slightly outside those reported previously single administration, therefore, follow-up combined extracts is required confirm how effects differ same cohort.